Transnitrosation Signals Oxyhemoglobin Desaturation
نویسندگان
چکیده
منابع مشابه
Transnitrosation signals oxyhemoglobin desaturation.
Erythrocytes dilate peripheral blood vessels as a function of oxyhemoglobin desaturation.1 This effect increases regional blood flow to hypoxic tissues. The mechanisms underlying the peripheral vasodilatory effects of desaturating erythrocytes are incompletely understood but do not involve activation of local, endothelial NO synthase (eNOS). Indeed, eNOS-derived NO itself primarily relaxes larg...
متن کاملPulmonary vascular hemodynamics in chronic lung disease patients with and without oxyhemoglobin desaturation during sleep.
Nonapneic, nocturnal oxyhemoglobin desaturation (NOD) during rapid-eye-movement (REM) sleep has been proposed as a predecessor and possible etiologic factor in the development of pulmonary hypertension in patients both with restrictive and obstructive chronic lung disease. The association between abnormal waking cardiopulmonary hemodynamics and NOD has not been established in patients with mild...
متن کاملNocturnal oxyhemoglobin desaturation and arteriopathy in a pediatric sickle cell disease cohort
OBJECTIVE The purpose of this study of sickle cell disease (SCD) was to determine whether arteriopathy, measurable as intracranial vessel signal loss on magnetic resonance angiography (MRA), was associated with low nocturnal hemoglobin oxygen saturation (SpO2) or hemolytic rate, measurable as reticulocytosis or unconjugated hyperbilirubinemia. METHODS Ninety-five East London children with SCD...
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We studied 152 COPD patients with a daytime PaO2 greater than or equal to 60 mm Hg using formal polysomnography (EEG, airflow, respiratory muscle movement, ear oximeter) to detect the presence of nocturnal, nonapneic, oxyhemoglobin desaturation. Nine subjects were disqualified by the unexpected discovery of sleep apnea, as were another eight because they could not sleep in the laboratory settin...
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Dr. Izbicki and colleagues1 are to be congratulated on their report of 26 patients with “sarcoid-like” granulomatous pulmonary disease (SLGPD) in Fire Department of New York (FDNY) World Trade Center (WTC) rescue workers. This adds to their previous descriptions of “WTC cough,” persistent airway hyperreactivity, and accelerated decline in lung function that have provided the largest share of th...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2008
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.108.183442